In Yokohama, players act as merchants, vying to gain fame through successful business ventures that include collecting trade goods, learning new technologies, and developing the citys shops and trading houses. To find new business, players will need to roam Yokohamas streets in search of opportunities. In Yokohama, players strategically dispatch assistants, navigate the city, and take actions to gain fame as merchants.

Each round consists of Additional and Main Actions, including placement, movement, area actions, and construction. Fulfilling achievements and order cards brings advantages. The game ends when players build all their Trading Houses/Shophouses, exhaust order cards, or meet specific assistant conditions. The player with the most fame wins.